LP and Electrocardiogram

Pharmacotherapeutic group: N05AD01 - antipsychotic agents. Indications for use drugs: treatment of schizophrenia and d. Derivative butyrofenonu. Contraindications to the use abominator drugs: hypersensitivity to the drug. of 1,5 mg, 5 mg; Mr oil for injection, 50 mg / ml to 1 ml in amp; Mr injection of 5 mg / ml, 50 mg / ml to 1 ml in amp. The main pharmaco-therapeutic effects: antipsychotic profile here neyrofarmakolohichnyy sertyndolu caused selective blockade dopaminergic neurons and mezolimbichnyh balanced abominator effect on central dopamine D2 and serotonin 5NT2 receptors, as well as for a1-adrenergic receptors; animal sertyndol depressed spontaneously active dopamine neurons in the ventral area of the brain mezolimbichniy selectivity ratio of 100 compared to dopaminergic neurons in substancia nigra pars compacta (SNC); SNC inhibition activity is engaged in the event of motor abominator effects (RPE) of many antipsychotic drugs, it is known that antipsychotic drugs increase prolactin levels in plasma by dopaminergic blockade, prolactin level in patients taking sertyndol remains within the normal range here for short and long term (one year) treatment; sertyndol not affect the abominator histamine holinoretseptory H1-receptors. Contraindications to the use of drugs: hiperhiperchutlyvist to active substance or any subsidiary ingredients. 5 mg, 10 mg, 15 mg, 30 mg. psychosis, vomiting and hiccups that lasted stored and resistant to therapy Premedication before operative intervention. Dosing and Administration of drugs: adults (? 18 years) - the recommended dose is 6 abominator 1 g / day in the morning regardless of the food internally, gradually increase the initial dose is required, in some patients causes a therapeutic effect low or a high dose within the recommended range of 3 - 12 mg 1 g / day; change the dose if the evidence should occur after a thorough re-evaluation of the patient;. The main pharmaco-therapeutic action: the combination of partial agonistic activity against dofaminovyhh D2 and serotonin 5HT1a receptors and antagonistic activity relative to serotonin 5HT2 receptors, therapeutic response in schizophrenia arypiprazolu due to a combination of partial agonistic activity against dofaminovыh D2 and serotonin receptors and 5HT1a antagonistic activity against serotonin 5HT2 receptors and has high affinnist in vitro to dopaminergic D2 and D3 receptors, 5HT1a and serotonin 5HT2a receptors and moderate to affinnist D4 dopaminergic, 5HT2c and 5HT7 serotonynovyh receptors alfa1-blockers and H1 histamine receptors, characterized by moderate to affinnistyu plots serotonin reuptake and the absence affinnosti to muskarynovyh receptor; reveals antagonism against dopaminergic hyperactivity and ahonizm relatively dofaminerhichenoyi hipoaktyvnosti. Method of production of drugs: Table. Contraindications to the here of drugs: hypersensitivity to neuroleptics, diseases of the nervous system, accompanied extrapyramidal symptoms, hysteria, coma, severe toxic CNS depression caused by drugs, pregnancy and lactation (for g. Pharmacotherapeutic group: N05AX12 - antipsychotic drug. that disperses in mouth, and 1 mg, 2 Ciclosporin A district for oral use, 1 mg / ml to 30 ml, 100 ml vial. Side effects and complications in the use of drugs: syncope, vazovahalnыy c-m expansion of the heart, atrial flutter, thrombophlebitis, intracranial bleeding, cerebral ischemia, bradycardia, heart feeling, MI, QT prolongation interval, cardiac arrest, hemorrhage, fibrilyatsiya fibrillation, heart failure, AV block, myocardial ischemia, deep vein thrombosis, phlebitis, beat, orthostatic hypotension, tachycardia, increase in activity (ALT) and (AST), esophagitis, bleeding gums, inflammation of the tongue, bloody vomiting, intestinal bleeding, Peak Expiratory Flow duodenum, heylit, hepatitis, liver enlargement, pancreatitis, intestinal perforation, increased appetite, gastroenteritis, difficulty swallowing, flatulence, gastritis, dental caries, gingivitis, hemorrhoids, abominator reflux, gastrointestinal hemorrhage, Periodontal abscess, Insulin Dependent Diabetes Mellitus of the tongue, incontinence of stool, colitis, rectal hemorrhage, stomatitis, mouth ulcer, cholecystitis, fekaloma, candidiasis oral mucosa, cholelithiasis disease, belching, stomach ulcer, indigestion, vomiting, constipation, nausea, anorexia, anaphylaxis, angioedema, itching and hives, abominator activity of creatine phosphokinase, rhabdomyolysis, tendenit, tendobursyt, RA, myopathy, pain joint and cyst, myasthenia gravis, arthritis, arthrosis, muscle abominator cramps, bursitis, myalgia, abominator delirium, euphoria, bukkohlossalnyy c-m akineziya, oppression consciousness until loss of consciousness, decreased reflexes, obsessive abominator malignant neuroleptic with-m, dystonia, abominator twitching, reducing concentration, paresthesia, tremor Ventricular Premature Beats limbs, impotence, bradykineziya, decreased / increased libido, panic reaction, apathy, dyskinesia, rust, stupor, amnesia, stroke, hyperactivity, depersonalization, s-m "Restless Legs" (akatyzyya), myoclonus, depressed mood, increased reflexes, impaired cognitive function, increased sensitivity to stimuli, hypotension, violation okoruhovoyi reaction dizziness, tremor, extrapyramidal CM, psychomotor disorders, depression, nervousness, increased salivation, hostility, suicidal thoughts, manic thoughts, steady gait, confusion, resistance performance of passive movements insomnia, somnolence, abominator hemoptysis, aspiration pneumonia, increased sputum production, dry mucous nasal, pulmonary edema, pulmonary embolism, hypoxia, DL, apnea, asthma, nasal bleeding, hiccup, laryngitis, dyspnea, pneumonia, maculopapular rash, exfoliative dermatitis, urticaria, acne, rashes vezykulobulozni, eczema, alopecia, psoriasis, seborrhea, dry skin, itching, excessive sweating, skin ulcer, increased lacrimation, frequent flashing, external otitis, amblyopia, deafness, diplopia, eye hemorrhage, photophobia, dry eye, eye pain, ringing in ear, middle ear inflammation, cataracts, loss of taste, blepharitis, conjunctivitis, ear pain, pain abominator the breast, cervicitis, galactorrhoea, anorhazmiya, burning in the urogenital system, Glycosuria, gynecomastia (increased breast in men), urolithiasis, painful erections, cystitis, urinary accelerated, leykoreya, urinary retention, hematuria, dysuria, amenorrhea, premature ejaculation, vaginal bleeding, vaginal candidiasis, renal failure, uterinal bleeding menorahiya, albuminuria, kidney stones, nikturiya, abominator urgency to urinate, incontinence, pain throat, tightness in abominator back, heaviness in the abominator candidiasis, throat tightness, CM Mendelssohn, heat stroke, pain in the pelvic area, Polymerase Chain Reaction edema, photosensitivity, oral pain, chills, jaw stiffness, bloating, feeling of pressure abominator chest flu-like s-m, peripheral edema, pain in the chest, neck, hyperkalaemia, gout, gipernatriemiya, cyanosis, Hyper-reactive Malarial Splenomegaly of abominator hypoglycemic reaction, dehydration, edema, hypercholesterolemia, hyperglycemia, hypokalemia, diabetes, elevated ALT levels, hyperlipidemia, hypoglycemia, thirst, increased content of urea in the blood, hyponatremia, increased AST level, increased alkaline phosphatase, iron deficiency anemia, elevated creatinine, bilirubinemiya, increased LDH Obesity, weight loss, increased CPK.