Currently, antithyroid funds are used mainly derivatives of thiourea pro-piltiouratsil and tiamazol (merkazolil), which inhibit snatch peroxidase and thus prevent iodination tyrosine residues of thyroglobulin-zines and violate the synthesis of T3 and T4. The cleavage of T3 and T4 from thyroglobulin occurs under the influence of lysosomal enzymes in epithelial cell follicle. Polypeptide hormone, parathyroid glands parathyroid hormone affects the exchange of calcium and phosphorus. When iodination of tyrosine formed T3 and T4. Side effects: headache, watery eyes, conjunctivitis, pain in the salivary glands, laryngitis, skin rash. In this case, insulin levels may be normal or even elevated. Effect develops after 30 minutes and lasts 6-8 hours in the field of hypodermic insulin may develop lipodystrophy, it is recommended to keep changing the injection site. This activates the carbohydrate, protein, snatch metabolism, increased frequency and strength of contractions of the heart, increases heat production. In the case of an overdose of insulin hypoglycemia develops. Diabetes mellitus type I (insulin-dependent) Carbon Dioxide associated with the destruction of ? cells of islets of Langerhans. In this regard, the action PTH increases the level of Ca 2 snatch in blood plasma. The drug is usually injected under the skin for 15-20 minutes before meals 1-3 times a day. Liotironin is faster and shorter than levothyroxine. Iodide (I) by active transport from blood plasma penetrates into epithelial cells nye forming follicles. However, their use may allergic reactions. Diabetes mellitus type II (insulin-independent) Reflex Anal Dilatation associated with a decrease in the Secretary-tion of insulin (? cells decrease in activity) or development of resistance of tissues to insulin. The main symptoms of diabetes type I diabetes: hyperglycemia, glycosuria, polyuria, thirst, polydipsia (in elevated fluid intake), ketonemiya, ketonuria, ketatsidoz. In diabetes mellitus type II is administered orally Hypogeum-likemicheskie means that when their insufficient efficiency combined with insulin preparations. For the first time a preparation containing insulin (extract from the pancreas of dogs) was obtained snatch the Canadian surgeon FG Banting and IV year student at CH Best at the University of Toronto in the laboratory of professor of physiology at Macleod and in 1922 applied for diabetes mellitus. In this snatch iodides reduce the synthesis and release T3 and T4 (reduced iodized-tion and proteolysis of thyroglobulin). Medicinal preparations, from rat parathyroid glands beef cattle parathyroidin injected subcutaneously or intramuscularly with hypoparathyroidism, spazmofilii. For insulin in medical practice Banting and Macleod received the Nobel Prize. Antithyroid tools used in hyperthyroidism (thyrotoxicosis, hyperthyroidism). Tsinksuspenziyu crystalline human insulin (ultratard snatch BBO-dyat just under the skin.
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